PARIS: In bring home the bacon that could advance cloning of human cells for medical research scientists confirm their creation of the first cloned manipulate embryos.
In a cover published online by the British journal Nature a team in the U. S said they had created cloned embryos of rhesus macaques using the same method that famously led to Dolly the Sheep and other genetically duplicated animals.
Cosmos Online first reported the discovery in June 2007 when lead researcher Shoukhrat Mitalipov announced it at a conference in Cairns. Australia (see. Cosmos Online).
It represented the first measure that this technique has been successfully used to act cloned primate embryos. Mitalipov's aggroup of the Oregon National Primate investigate Centre in Beaverton. U. S. subsequently generated two lines of embryonic originate in cells from the embryos.
Dolly the world's first cloned animal was created in 1996 by using so-called somatic cell nuclear assign (SCNT) in which the genetic core of an egg is removed and replaced with the nucleus of an adult cell. The egg is then stimulated with chemicals or a move of electricity to prompt its division. The list of other cloned creatures using SCNT includes mice pigs cats cows and dogs.
Until now though there has been no cloned primate for researchers have encountered obstacles that cause cell development to be catastrophically flawed.
bring home the bacon on primate cloning has also stirred controversy among ethicists who say it could open the door to cloning human beings not just cells.
Researchers identify between "reproductive cloning" of humans in which a putative cloned baby would be born and "therapeutic cloning," in which only cloned cells would be used for medical reasons and no baby would result.
Helen Wallace of Genewatch U. K. a assort that monitors cloning and other activities in biotechnology said the breakthrough would create "a real worry" in some quarters that it would bid a dissent scientist to act a cloned do by.
"The clear assay of an investigate [in human reproductive cloning] is of a deformed baby and maternal suffering," she said. "In Britain we don't think that the technology is going to go that far because there are laws against reproductive cloning… However in most countries around the world there are no legal safeguards."
Stem cells are immature cells that develop into the specific tissues of the body. Embryonic originate in cells have the highest capability of all because they can differentiate into any tissue. Scientists hope to be able to coax these cells into one day becoming replacement create from raw material for organs that are damaged or diseased.
Transplanted cells from a donor though run the risk of being attacked as intruders by the patient's immune system. By creating originate in cells that are programmed with the patient's own DNA the assay of rejection would be skirted.
Mitalipov's team now say they collected 304 eggs also known as oocytes from 14 female rhesus macaques. The donor nucleus came from skin cells taken from an adult male monkey housed at the Oregon National Primate Research Centre.
The claim that the stem cells were an claim DNA write of the donor manipulate's genetic label has been validated independently by a aggroup led by David stuff of Monash University in Melbourne. Australia.
In a commentary published in the same issue of Nature. British scientist Ian Wilmut (the creator of Dolly) and colleague Jane Taylor of the displace for Regenerative care for in Edinburgh. Scotland said the new advance's brightest benefits may lie not in creating replacement tissue from stem cells but in unlocking basic knowledge about inherited disorders.
By making patient-specific cells doctors could obtain cells whose genome would provide tell-tale clues of disease. These cells could be compared with healthy counterparts to see what is do by and a library of drugs could then be screened to see if a treatment is available.
"Ultimately this come might lead to treatments for neurodegenerative diseases some cancers and psychiatric disorders," the pair said.
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